Home instrument HRMS SELECT SERIES Cyclic IMS

Ultimate power, ultimate performance. Redefine the boundaries of science.

Developed through focused collaboration, the SELECT SERIES Cyclic IMS combines novel cyclic ion mobility separation with state-of-the-art high performance, time-of-flight mass spectrometry, enabling leading researchers to unlock the potential in scientific discovery.

  • Extends the benefits of routine ion mobility
  • Provides variable, high-resolution ion mobility separations
  • Introduces the unique ability to perform ion mobility/ion mobility and IMSn experiments.

Revolutionary Cyclic Ion Mobility

Ion mobility is an established technique in many applications. When coupled to mass spectrometry, it provides:

  • The ability to separate on shape as well as m/z, enabling separation of isomers
  • Significantly cleaner mass spectral data
  • A measure of the ions Collisional Cross Section (CCS).

The circular path of the Cyclic Ion Mobility (cIM) device minimises instrument footprint whilst providing precise collisional cross section values (<0.5% RSD), multi pass variable, high resolution (>400) ion mobility separations and IMSn.

Discover more with ultimate ion mobility resolution

The instrument design and control software enables a range of experiments, including acquisition of Tof data, Single pass ion mobility, and the ability to scale mobility resolution to match the complexity of a sample. Ion mobility resolution increases with the length of the mobility device and therefore with the number of passes.

Unlock the potential in scientific discovery

The unique instrument design facilitates advanced ion mobilty experiments.

Undertake advanced structural characterization

IMSn Activation – For advanced structural characterisation.

Collision Induced Dissociation (CID)

The traditional collision induced dissociation (CID) technique accelerates gaseous ions into a dense gas filled chamber of the mass spectrometer where collision with a neutral species (e.g., nitrogen or argon) causes bonds to break and fragmentation to occur.

Electron Capture Dissociation (ECD)

ECD is initiated by electron attachment/transfer to multiply-protonated molecules, which induces cleavage at N–Cα bonds, in a peptide backbone. ECD preserves unstable side-chain modifications during fragmentation and generates complementary data to CID providing more detailed structural information, increased sequence coverage and greater confidence for more complete characterization of proteins, PTMs, and glycans.

Surface Induce Dissociation (SID)

The combination of CID, ECD and SID with cyclic ion mobility provides a significantly enhanced tool set for protein characterization.

Imaging mass spectrometry with DESI XS and Cyclic IMS

The unique combination of DESI XS with SELECT SERIES Cyclic IMS provides ultimate levels of specificity for MS imaging approaches. DESI XS produces a visual map of the spatial distribution of a wide range of analytes, for example small molecule drugs, metabolites and lipids across the surface of a tissue sample, and the unique capabilities and modes of acquisition of Cyclic IMS enable comprehensive in-depth experiments to be performed.

The SELECT SERIES Cyclic IMS Brochure