ACQUITY Arc System

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HPLC and UHPLC method compatibility at the flip of a switch

The ACQUITY Arc System is a quaternary-based, modern LC system for scientists working with established methods who are looking for the versatility and robustness required to bridge the gap between HPLC and UPLC while continuing to support validated assays.

  • Regulatory compliant-ready hardware and software for both HPLC and UHPLC separations in one instrument
  • Get mass detection, without changing the way you work, with the ACQUITY QDa Detector
  • Deploy the benefits of 2.x μm particle columns to boost the chromatographic performance of your methods
  • On-demand mobile phase creation with Auto●Blend Plus Technology, eliminating the cumbersome and error-prone approach of manual preparation

Replicate your established methods

The ACQUITY Arc System can replicate your established HPLC methods by compensating for these differences with unique features such as the Arc Multi-Flow Path technology and Gradient SmartStart. These innovative attributes enable seamless replication of your existing chromatographic results to meet your acceptance criteria without changes to validated gradient tables.

Get seamless and efficient transfer, adjustment, or improvement of methods from any LC platform without compromise in method integrity or changes to validated gradient tables.

Go from HPLC to UHPLC with the flip of a switch

The ACQUITY Arc System is enabled by Arc Multi-flow path technology, novel technology that enables the user to easily switch between HPLC and UHPLC operation by selecting the dwell volume that best fits the column separation. System reliability and robustness ensures product consistency and compliance with regulatory guidelines, all while minimizing downtown and inefficiencies.

With the ACQUITY Arc System, maximize productivity through combining system dispersion characteristics with efficient and rapid 2.x um UHPLC separations. Or, accommodate larger, 3.0 – 5.0 um particles. This provides the flexibility to support a wide-range of LC applications.

Simplify your daily set-up

Improve your laboratory workflow with advanced software capabilities.

  • Fully automate your daily system start-up, including system priming and equilibration, with Empower 3 Software
  • Get real-time information on all of system components in one location, with a simple and intuitive interface using Instrument Console Software
  • Prepare your pH buffers online from pure solvents, significantly reducing the time it takes to prepare mobile phases while improving the day-to-day repeatability of your preparations with Auto●Blend Plus Technology

Develop methods that stand the test of time 

Need an orthogonal detection approach to UV in your method development? Streamline your method development with an LC-MS solution that’s as easy to use as photodiode array detection.

The ACQUITY Arc System is fully compatible with the ACQUITY QDa Mass Detector, supporting efficient and robust method development by expanding the information you can get from your system using the same Empower Software. The system automatically pairs qualitative mass spectral data to the peaks in your chromatogram leaving nothing to chance.

  • Confirm the identity of peaks in a separation without injecting standards
  • Identify new peaks in a separation with molecular weight information
  • Detect unresolved peaks and determine if a peak is homogenously pure
  • Easily track peaks as method conditions are changed

Method transfer of USP Assay for Fluconazole using the ACQUITY Arc System. Here the peak has same m/z of a related compound. 1. Related compound A; 2. Related compound B; 3. Related compound C; 4. Fluconazole. 

Features and Benefits

  • Quaternary solvent blending. Blend up to four solvents in any combination or proportion. Expand to up to nine solvent choices with the optional and integrated solvent-select valve for even greater flexibility.
  • Plug-and-play method compatibility with HPLC or UHPLC with the flip of a switch. Easily replicate or improve established methods by simply selecting Path 1 (HPLC) or Path 2 (UHPLC) without any manual user intervention. Automatically counteract differences in system dwell volume without the need to alter gradient table inputs.
  • Minimize carryover (≤0.002%) by continuously cleansing the needle during the run with an advanced flow-through-needle design.
  • Flexible column manager options available for up to 15 columns ranging in length from 50 mm to 300 mm, with a temperature range of 4 °C to 90 °C. Provide stable, uniform temperature management with integrated active or passive pre-heating options to ensure method repeatability from lab to lab. Optional and integrated column selection valve provide fast, unattended column changeover.
  • Directly program gradients in units of pH and ionic strength with Auto●Blend Plus Technology, providing the ability to vary composition in even the smallest increments of pH. This eliminates the cumbersome and error-prone approach of manually preparing mobile phase solutions.
  • Maximize HPLC and UHPLC performance with a full line of optical detection options.
  • Push-button mass detection with the ACQUITY QDa Mass Detector.
  • Compliance-ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others.  The ACQUITY Arc System supports Waters Empower based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification.
  • Consumables. Industry leading selectivity choices to meet the needs of virtually every LC application. Quality Control Reference Material benchmarks your ACQUITY Arc System and enables perfect resolution. Certified clean vials.

Supported in both Empower and MassLynx Software.

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